Efficient methods for DNA detectionin clinical, environmental, and experimental samples are constantly in demand. In a clinical sample, DNA capture and identification can be essential to the diagnosis of disease. In public heath and environmental situations it can be used to identify contamination of food or water. DNA collection and characterization is constantly expanding our ability to answer experimental questions. DNA capture is a mainstay of modern biotechnology. Traditional techniques rely on affinity columns, centrifugation, and multiple washing steps. Newer methods are based on magnetic separation. In the beginning,magnetic separation was limitedto packing a column with magnetic material and running a solution through it. As nanotechnology evolved it became possible to use mobile solid support systems such as magnetic nanoparticles.