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Posted on Wed, Feb 20, 2013

Introducing Homogenous Biomagnetic Separation

Traditional biomagnetic separation techniques have several drawbacks that affect both the quality and the quantity of the final product.

In a traditional separator, the magnitude of the magnetic field experienced by the bead is dependent on the distance from the magnet. When this happens, magnetic beads are either lost in the production process (i.e. beads far from the magnet exposed to low magnetic force) or aggregate, sometimes irreversibly (i.e. beads close to the magnet exposed to high magnetic forces over an extended period of time).

Free PDF guide:   "Validation of Magnetic Bead Separation Processes" 

Trying to balance these two opposing difficulties in order to gain the best yield is extremely difficult. Trying to standardize the balance and extrapolate the parameters to different batch sizes is almost always impossible. Because of these difficulties, traditional biomagnetic separation processes suffer from a lack of lot to lot consistency.

Homogenous biomagnetic separation devices such as Sepmag alleviate these difficulties through a unique design of the apparatus. Sepmag devices are designed as cylinders which allow the beads to experience the same magnetic force no matter how far from the magnet they are. This innovative technology decreases the time of separation, significantly decreases or eliminates bead aggregation and increases yield.

In addition, since the magnetic force felt by the beads is independent of distance from the magnet, the final yields are reproducible and consistent. Parameters are well defined in homogenous biomagnetic separation devices such as Sepmag and are reproducible and scalable.

Furthermore, processes can be monitored over time and compared against a standard curve, allowing technicians and scientists to visualize the process as it occurs and make adjustments as necessary. Batch yields and quality are consistent, saving companies precious financial resources, manpower and production time. 

biomagnetic separation processes

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