Today we'll learn more about breaking up irreversible magnetic bead aggregates with different methods such as the sonication method, are you ready?
The problems with magnetic bead suspensions
The major problem with non-colloidal solids suspended in liquids is that they will eventually sediment and clump over time. Magnetic bead suspensions are no exception. Even though magnetic separation is generally gentler than separation by centrifugation, clumps and aggregates can still form. Aggregate formation happens at a much greater frequency if you do not use homogenous biomagnetic separation conditions.