In a recent study published in “Angewandte Chemie,” researchers report the development of iron oxide nanoparticles capable of self-assembling when placed in a tumor environment. Self-assembly into larger aggregates significantly improved magnetic resonance imaging (MRI) of cancer cells. The research, carried out by a team of scientists at the Imperial College London, has significant implications for the early detection and treatment of cancer.
A team of physicists at the University of Texas (UT) recently reported success coupling continuous wave near-infrared laser beams with crystalline magnetic carbon nanoparticles to introduce therapeutic agents into cancer cells. The study, which appears in “Nature Scientific Reports,” introduces an alternate and viable approach to cell targeting and drug delivery methods.
The principle behind quadrapeutics involves four existing clinical treatments: radiotherapy, low-energy laser pulses, targeted drug delivery, and colloidal gold nanoparticles. The protocol was developed to treat chemoradiation-resistant tumors. Preclinical studies, led by Dmitri Lapotko at Rice University in Texas, recently showed a 17-fold improvement in treating aggressive, drug-resistant cancer in vivo. What’s more, the procedure specifically targeted cancer cells, leaving healthy cells unharmed.
The American Association for Clinical Chemistry (AACC) will be holding its annual meeting this year on July 27 – July 31. The meeting will take place at McCormick Place, located on Lake Michigan in Chicago, Illinois. Over 20,000 laboratory medicine professionals are expected to attend, taking part in the main conference as well as the Clinical Lab Expo. Participants will include scientists and clinicians interested in the fields of clinical chemistry and the clinical laboratory sciences.
In order to efficiently utilize nanoparticles in imaging and diagnostic applications, it is critical to distinguish particles that have been internalized by their cellular target from those that have not. The ability to differentiate between the two is essential for quantification and visualization, as well as determining the efficiency of drug delivery protocols.
The Biotechnology Industry Organization (BIO) will host its annual convention on June 23-36 in San Diego, California this year. The BIO International Convention is the largest biotechnology event of its kind, drawing thousands of attendees. Participants will be able to choose from hundreds of sessions regarding trends in biotechnology, policy, and innovations, as well as being granted access to the world’s largest biotechnology exhibition.
Last May I was in Shanghai, invited by Merck Millipore to contribute to the Forum they organized. SEPMAG was one of the sponsors and I was one of the speakers. In a previous post I have reviewed the talks about new trends on immunomagnetic assays, coupling of biomarkers and the use of Biomagnetic Separation in CLIA IVD-kits Manufacture.
When a nanoparticle is introduced into a physical medium such as human plasma, its surface becomes coated by a layer of proteins, yielding a protein corona whose composition greatly influences the way the nanoparticle interacts with tissues and cells, as well as its ultimate biological fate. Different factors, including protein concentration, post-translational modifications, structure, and solubility, all play a role in determining the corona’s make-up. Any circumstance that impacts these factors, such as disease or genetic background, is therefore also likely to impact the composition of the protein corona.
Two draft maps of the human proteome have been published in the latest issue of Nature. The drafts were produced by two separate international research teams working independently of one another. Using mass-spectrometry to analyze tissue, body fluids, and cells, the teams have catalogued the proteins that are found in a non-diseased state and identified novel proteins expressed from what was previously thought to be non-coding or junk DNA.
