https://www.sepmag.eu/zh/blog en Wed, 22 Apr 2020 13:11:04 GMT 2020-04-22T13:11:04Z en https://www.sepmag.eu/zh/blog/scale-up-challenges-in-biomagnetic-separation-processes <div class="hs-featured-image-wrapper"> <a href="https://www.sepmag.eu/zh/blog/scale-up-challenges-in-biomagnetic-separation-processes" title="" class="hs-featured-image-link"> <img src="https://www.sepmag.eu/hs-fs/hubfs/images/Scaling-up_7_keys/Key6Fig3.png?width=545&amp;name=Key6Fig3.png" alt="在生物磁性分离过程中的放大挑战" class="hs-featured-image" style="width:auto !important; max-width:50%; float:left; margin:0 15px 15px 0;"> </a> </div> <p>在过去的20年间，我们见证了磁珠在生命科学领域应用的爆发式增长，整个行业的销售额维持了双位数增长。这一成功的主要驱动力是应用磁珠作为化学免疫发光测定（CLIA）试剂盒的固相载体。由于其易于自动化，这项技术已成为高通量体外诊断的优选。</p> <div class="hs-featured-image-wrapper"> <a href="https://www.sepmag.eu/zh/blog/scale-up-challenges-in-biomagnetic-separation-processes" title="" class="hs-featured-image-link"> <img src="https://www.sepmag.eu/hs-fs/hubfs/images/Scaling-up_7_keys/Key6Fig3.png?width=545&amp;name=Key6Fig3.png" alt="在生物磁性分离过程中的放大挑战" class="hs-featured-image" style="width:auto !important; max-width:50%; float:left; margin:0 15px 15px 0;"> </a> </div> <p>在过去的20年间，我们见证了磁珠在生命科学领域应用的爆发式增长，整个行业的销售额维持了双位数增长。这一成功的主要驱动力是应用磁珠作为化学免疫发光测定（CLIA）试剂盒的固相载体。由于其易于自动化，这项技术已成为高通量体外诊断的优选。</p> <img src="https://track.hubspot.com/__ptq.gif?a=213437&amp;k=14&amp;r=https%3A%2F%2Fwww.sepmag.eu%2Fzh%2Fblog%2Fscale-up-challenges-in-biomagnetic-separation-processes&amp;bu=https%253A%252F%252Fwww.sepmag.eu%252Fzh%252Fblog&amp;bvt=rss" alt="" width="1" height="1" style="min-height:1px!important;width:1px!important;border-width:0!important;margin-top:0!important;margin-bottom:0!important;margin-right:0!important;margin-left:0!important;padding-top:0!important;padding-bottom:0!important;padding-right:0!important;padding-left:0!important; "> 放大生物磁性分离过程 (scaling biomag separ proc) Fri, 06 Mar 2020 10:38:25 GMT https://www.sepmag.eu/zh/blog/scale-up-challenges-in-biomagnetic-separation-processes 2020-03-06T10:38:25Z Lluis M. Martínez, SEPMAG首席科学官 https://www.sepmag.eu/zh/blog/avoiding-irreversible-aggregation-problems-during-production <div class="hs-featured-image-wrapper"> <a href="https://www.sepmag.eu/zh/blog/avoiding-irreversible-aggregation-problems-during-production" title="" class="hs-featured-image-link"> <img src="https://www.sepmag.eu/hs-fs/hub/213437/file-30046816-png/images/mofu2_chapter_6-resized-600.png?width=510&amp;height=376&amp;name=mofu2_chapter_6-resized-600.png" alt="避免生产过程中不可逆的聚集问题" class="hs-featured-image" style="width:auto !important; max-width:50%; float:left; margin:0 15px 15px 0;"> </a> </div> <p>批次内的一致性是在<strong>试剂盒水平</strong>上保证可复性的<strong>关键</strong>。不幸的是，在非均质系统中，<strong>不可逆聚集</strong>是批次内变异的主要缘由之一。如果所有的磁珠暴露于同质的磁性系统中，受到相同的磁力，则聚集的风险会大大降低。因此，知道在<strong>磁性分离过程</strong>中如何<strong>避免不可逆聚集</strong>是非常重要的。</p> <div class="hs-featured-image-wrapper"> <a href="https://www.sepmag.eu/zh/blog/avoiding-irreversible-aggregation-problems-during-production" title="" class="hs-featured-image-link"> <img src="https://www.sepmag.eu/hs-fs/hub/213437/file-30046816-png/images/mofu2_chapter_6-resized-600.png?width=510&amp;height=376&amp;name=mofu2_chapter_6-resized-600.png" alt="避免生产过程中不可逆的聚集问题" class="hs-featured-image" style="width:auto !important; max-width:50%; float:left; margin:0 15px 15px 0;"> </a> </div> <p>批次内的一致性是在<strong>试剂盒水平</strong>上保证可复性的<strong>关键</strong>。不幸的是，在非均质系统中，<strong>不可逆聚集</strong>是批次内变异的主要缘由之一。如果所有的磁珠暴露于同质的磁性系统中，受到相同的磁力，则聚集的风险会大大降低。因此，知道在<strong>磁性分离过程</strong>中如何<strong>避免不可逆聚集</strong>是非常重要的。</p> <img src="https://track.hubspot.com/__ptq.gif?a=213437&amp;k=14&amp;r=https%3A%2F%2Fwww.sepmag.eu%2Fzh%2Fblog%2Favoiding-irreversible-aggregation-problems-during-production&amp;bu=https%253A%252F%252Fwww.sepmag.eu%252Fzh%252Fblog&amp;bvt=rss" alt="" width="1" height="1" style="min-height:1px!important;width:1px!important;border-width:0!important;margin-top:0!important;margin-bottom:0!important;margin-right:0!important;margin-left:0!important;padding-top:0!important;padding-bottom:0!important;padding-right:0!important;padding-left:0!important; "> Fri, 06 Mar 2020 10:38:07 GMT https://www.sepmag.eu/zh/blog/avoiding-irreversible-aggregation-problems-during-production 2020-03-06T10:38:07Z Lluis M. Martínez, SEPMAG首席科学官 https://www.sepmag.eu/zh/blog/why-monitor-biomagnetic-separation-processes <div class="hs-featured-image-wrapper"> <a href="https://www.sepmag.eu/zh/blog/why-monitor-biomagnetic-separation-processes" title="" class="hs-featured-image-link"> <img src="https://www.sepmag.eu/hs-fs/hub/213437/file-2670990748-png/images/monitoring_biomagnetic_separation/Capitol3Figura1.png?width=616&amp;name=Capitol3Figura1.png" alt="为何在研发时监测生物磁性分离过程？" class="hs-featured-image" style="width:auto !important; max-width:50%; float:left; margin:0 15px 15px 0;"> </a> </div> <p>磁性分离器在生命科学领域有着众多的应用。从细胞分选到分子诊断，这项技术适用于几纳升（芯片实验室）到几十升（生产IVD（体外诊断）试剂）的体积。</p> <div class="hs-featured-image-wrapper"> <a href="https://www.sepmag.eu/zh/blog/why-monitor-biomagnetic-separation-processes" title="" class="hs-featured-image-link"> <img src="https://www.sepmag.eu/hs-fs/hub/213437/file-2670990748-png/images/monitoring_biomagnetic_separation/Capitol3Figura1.png?width=616&amp;name=Capitol3Figura1.png" alt="为何在研发时监测生物磁性分离过程？" class="hs-featured-image" style="width:auto !important; max-width:50%; float:left; margin:0 15px 15px 0;"> </a> </div> <p>磁性分离器在生命科学领域有着众多的应用。从细胞分选到分子诊断，这项技术适用于几纳升（芯片实验室）到几十升（生产IVD（体外诊断）试剂）的体积。</p> <img src="https://track.hubspot.com/__ptq.gif?a=213437&amp;k=14&amp;r=https%3A%2F%2Fwww.sepmag.eu%2Fzh%2Fblog%2Fwhy-monitor-biomagnetic-separation-processes&amp;bu=https%253A%252F%252Fwww.sepmag.eu%252Fzh%252Fblog&amp;bvt=rss" alt="" width="1" height="1" style="min-height:1px!important;width:1px!important;border-width:0!important;margin-top:0!important;margin-bottom:0!important;margin-right:0!important;margin-left:0!important;padding-top:0!important;padding-bottom:0!important;padding-right:0!important;padding-left:0!important; "> Fri, 06 Mar 2020 10:37:53 GMT https://www.sepmag.eu/zh/blog/why-monitor-biomagnetic-separation-processes 2020-03-06T10:37:53Z Lluis M. Martínez, SEPMAG首席科学官 https://www.sepmag.eu/zh/blog/how-does-magnetic-bead-separation-work <div class="hs-featured-image-wrapper"> <a href="https://www.sepmag.eu/zh/blog/how-does-magnetic-bead-separation-work" title="" class="hs-featured-image-link"> <img src="https://www.sepmag.eu/hs-fs/hub/213437/file-365047521-png/images/bead_dynamics_magnetic_bead_separation.png?width=500&amp;height=355&amp;name=bead_dynamics_magnetic_bead_separation.png" alt="磁珠分离是如何工作的？" class="hs-featured-image" style="width:auto !important; max-width:50%; float:left; margin:0 15px 15px 0;"> </a> </div> <p><strong>磁珠分离</strong>是一种快速，高效，清洁的过程，科学家用其取代过滤，离心和分离技术。磁珠和磁微粒通过功能化的抗原，抗体，<strong>催化剂</strong>，蛋白或核酸发挥作用，对细胞，细菌，病毒和其他生物体发挥作用。</p> <div class="hs-featured-image-wrapper"> <a href="https://www.sepmag.eu/zh/blog/how-does-magnetic-bead-separation-work" title="" class="hs-featured-image-link"> <img src="https://www.sepmag.eu/hs-fs/hub/213437/file-365047521-png/images/bead_dynamics_magnetic_bead_separation.png?width=500&amp;height=355&amp;name=bead_dynamics_magnetic_bead_separation.png" alt="磁珠分离是如何工作的？" class="hs-featured-image" style="width:auto !important; max-width:50%; float:left; margin:0 15px 15px 0;"> </a> </div> <p><strong>磁珠分离</strong>是一种快速，高效，清洁的过程，科学家用其取代过滤，离心和分离技术。磁珠和磁微粒通过功能化的抗原，抗体，<strong>催化剂</strong>，蛋白或核酸发挥作用，对细胞，细菌，病毒和其他生物体发挥作用。</p> <img src="https://track.hubspot.com/__ptq.gif?a=213437&amp;k=14&amp;r=https%3A%2F%2Fwww.sepmag.eu%2Fzh%2Fblog%2Fhow-does-magnetic-bead-separation-work&amp;bu=https%253A%252F%252Fwww.sepmag.eu%252Fzh%252Fblog&amp;bvt=rss" alt="" width="1" height="1" style="min-height:1px!important;width:1px!important;border-width:0!important;margin-top:0!important;margin-bottom:0!important;margin-right:0!important;margin-left:0!important;padding-top:0!important;padding-bottom:0!important;padding-right:0!important;padding-left:0!important; "> Fri, 06 Mar 2020 10:37:38 GMT https://www.sepmag.eu/zh/blog/how-does-magnetic-bead-separation-work 2020-03-06T10:37:38Z Lluis M. Martínez, SEPMAG首席科学官